1, 4-DPCA --- Prolyl 4-hydroxylase (P4H) Inhibitor
| Overview | |
| Catalog # | bs-60288C |
| Product Name | 1, 4-DPCA --- Prolyl 4-hydroxylase (P4H) Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 240.21 Formula: C13 H8 N2 O3 CAS Number: 331830-20-7 InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N InChi: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18) Smiles: OC(=O)C1=CNC2C(=CC=C3C=CC=NC3=2)C1=O Purity: 98.0 Solubility: DMSO up to 10 mM, EtOH up to 20 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | 1, 4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis. |
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