Recombinant Human ACE2 Protein
| OVERVIEW | |
| CATALOG # | bs46110P |
| PRODUCT NAME | Recombinant Human ACE2 Protein |
| CROSS REACTIVE SPECIES DETAILS | Homo sapiens (Human) |
| CONJUGATION | Unconjugated |
| SOURCE | Recombinant Human ACE2 is produced by Mammalian cells expression system and the target gene encoding Met1-Ser740 is expressed with C-His Tag |
| EXPRESSION SYSTEM | Mammalian cells |
| TAG | C-His Tag |
| PREDICTED MOLECULAR MASS | 86.28kDa |
| PURITY | >95% as determined by SDS-PAGE |
| FORMULATION |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). 5 % trehalose is added as a protectant |
| STORAGE | Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt. Avoid repeated freeze/thaw cycles. |
| ENDOTOXIN LEVEL | N/A |
| ACTIVITY ASSAY | N/A |
| TARGET | |
| ACCESSION # | NP_001358344.1 |
| SYNONYMS | ACE-related carboxypeptidase Angiotensin-converting enzyme homolog Metalloprotease MPROT15 |
| BACKGROUND | Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. The ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be highly expressed in testis, kidney, and heart, in the colon, small intestine, and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor, don’t inhibit ACE-2 activity. ACE-2 may play an essential role in regulating heart function. |
| NOTE | For research use only. Not for use in clinical diagnostic procedures. |