Recombinant Human ACE2 Protein

OVERVIEW
CATALOG # bs46110P
PRODUCT NAME Recombinant Human ACE2 Protein
CROSS REACTIVE SPECIES DETAILS Homo sapiens (Human)
CONJUGATION Unconjugated
SOURCE Recombinant Human ACE2 is produced by Mammalian cells expression system and the target gene encoding Met1-Ser740 is expressed with C-His Tag
EXPRESSION SYSTEM Mammalian cells
TAG C-His Tag
PREDICTED MOLECULAR MASS 86.28kDa
PURITY >95% as determined by SDS-PAGE
FORMULATION

Lyophilized from 0.22um filtered solution in PBS (pH 7.4). 5 % trehalose is added as a protectant

STORAGE Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt. Avoid repeated freeze/thaw cycles.
ENDOTOXIN LEVEL N/A
ACTIVITY ASSAY N/A
TARGET
ACCESSION # NP_001358344.1
SYNONYMS ACE-related carboxypeptidase
Angiotensin-converting enzyme homolog
Metalloprotease MPROT15
BACKGROUND Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. The ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be highly expressed in testis, kidney, and heart, in the colon, small intestine, and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor, don’t inhibit ACE-2 activity. ACE-2 may play an essential role in regulating heart function.
NOTE For research use only. Not for use in clinical diagnostic procedures.