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    presenilin 1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

    Overview
    Catalog # bs-0025M-A647
    Product Name presenilin 1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Rat, Rabbit
    Specifications
    Conjugation ALEXA FLUOR® 647
    Host Mouse
    Source KLH conjugated synthetic peptide derived from human Presenilin-1 CTF subunit
    Immunogen Range 250-300/467
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 19164
    Swiss Prot P49769
    Subcellular location Cytoplasm
    Synonyms PS1; Ad3h; PS-1; S182; Presenilin-1; Protein S182; Psen1; Psnl1
    Background Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).