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    AIF Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

    Catalog # bs-0037R-A647
    Product Name AIF Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat, Pig
    Conjugation ALEXA FLUOR® 647
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human AIF
    Immunogen Range 130-180/613
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Gene ID 9131
    Swiss Prot O95831
    Subcellular location Cytoplasm, Mitochondrion
    Synonyms AIF; CMT2D; CMTX4; COWCK; NADMR; NAMSD; PDCD8; COXPD6; Apoptosis-inducing factor 1, mitochondrial; Programmed cell death protein 8; AIFM1
    Background Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.