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    Caspase 3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated

    Overview
    Catalog # bs-0081R-A350
    Product Name Caspase 3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
    Applications IF(IHC-P), IF(ICC)
    Reactivity Human, Mouse, Rat, Bovine, Goat
    Specifications
    Conjugation ALEXA FLUOR® 350
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Caspase 3(Active)
    Immunogen Range 60-100/277
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 836
    Swiss Prot P42574
    Subcellular location Cytoplasm
    Synonyms CPP32; SCA-1; CPP32B; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; CASP3
    Background Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.