0 Cart
Added to Cart
    You have items in your cart
    You have 1 item in your cart
    Total
    Check Out Continue Shopping
    `

    PKM2 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated

    Overview
    Catalog # bs-0101R-A594
    Product Name PKM2 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 594
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from mouse Pyruvate kinase PKM
    Immunogen Range 293-340/531
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 5315, 5313
    Swiss Prot P14618, P30613
    Subcellular location Cytoplasm
    Synonyms PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-3; Pyruvate kinase PKM; Cytosolic thyroid hormone-binding protein; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Tumor M2-PK; p58; PKM; PK2; Pyruvate kinase PKLR; Pyruvate kinase 1; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase.
    Background Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.