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    FE65 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated

    Overview
    Catalog # bs-0110R-A594
    Product Name FE65 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 594
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Fe65 protein
    Immunogen Range 225-265/710
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 322
    Swiss Prot O00213
    Subcellular location Cytoplasm, Nucleus, Cell membrane
    Synonyms RIR; FE65; MGC:9072; Amyloid beta A4 precursor protein-binding family B member 1; Protein Fe65; APBB1
    Background Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).