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    SOCS1 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated

    Description:
    Applications:
    • IF(IHC-P)
    Overview
    Catalog # bs-0113R-A594
    Product Name SOCS1 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 594
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Socs 1
    Immunogen Range 160-211/211
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 8651
    Swiss Prot O15524
    Subcellular location Nucleus
    Synonyms JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; Suppressor of cytokine signaling 1; JAK-binding protein; STAT-induced STAT inhibitor 1; Tec-interacting protein 3; TIP-3; SOCS1
    Background SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
    Applications
    Application Dilution
    IF(IHC-P) 1:50-200