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    PTP1B Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated

    Overview
    Catalog # bs-0182R-A488
    Product Name PTP1B Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 488
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human PTP-1B
    Immunogen Range 13-65/435
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 5770
    Swiss Prot P18031
    Subcellular location Cytoplasm
    Synonyms PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1
    Background Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.