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    Integrin beta 1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated

    Description:
    Applications:
    • IF(IHC-P)
    • IF(ICC)
    Overview
    Catalog # bs-0486R-A488
    Product Name Integrin beta 1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
    Applications IF(IHC-P), IF(ICC)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 488
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Integrin beta 1
    Immunogen Range 10-60/798
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 3688
    Swiss Prot P05556
    Subcellular location Extracellular
    Synonyms CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; VLA-4 subunit beta; ITGB1
    Background Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    Applications
    Application Dilution
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200