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    Angiopoietin 2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated

    Overview
    Catalog # bs-0677R-A350
    Product Name Angiopoietin 2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat, Pig
    Specifications
    Conjugation ALEXA FLUOR® 350
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Angiopoietin 2
    Immunogen Range 450-490/496
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 285
    Swiss Prot O15123
    Subcellular location Secreted
    Synonyms ANG2; AGPT2; Angiopoietin-2; ANG-2; ANGPT2
    Background Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.