Collagen 4 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated

Applications

  • IF(IHC-P)

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-0806R-A488
Product Name Collagen 4 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
Applications IF(IHC-P)
Specificity This antibody has 79% cross reactivity with Collagen alpha-5(IV) chain.
Reactivity Human, Mouse, Rat
Specifications
Conjugation ALEXA FLUOR® 488
Host Rabbit
Source KLH conjugated synthetic peptide derived from mouse Collagen alpha-1(IV) chain
Immunogen Range 1430-1480/1669
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target
Gene ID 12826
Swiss Prot P02463
Subcellular location Secreted
Synonyms Bru; Raw; Svc; Col4a-1; Del(8)44H; Collagen alpha-1(IV) chain; Col4a1
Background Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin (By similarity).
Application Dilution
IF(IHC-P) 1:50-200