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    GDAP1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

    Catalog # bs-11725R-A647
    Product Name GDAP1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Conjugation ALEXA FLUOR® 647
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human GDAP1
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Synonyms Ganglioside induced dferentiation associated protein 1; Ganglioside-induced dferentiation-associated protein 1; GDAP1; GDAP1_HUMAN.
    Background Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.