Frizzled 9/CD349 Polyclonal Antibody, Biotin Conjugated

Applications

  • WB
  • ELISA

Reactivity

  • Human

Predicted Reactivity

  • Mouse
  • Rat
Overview
Catalog # bs-11842R-Biotin
Product Name Frizzled 9/CD349 Polyclonal Antibody, Biotin Conjugated
Applications WB, ELISA
Specificity This antibody may have slight cross reactivity with Frizzled 10.
Reactivity Human
Predicted Reactivity Mouse, Rat
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Frizzled 9/CD349
Immunogen Range 185-270/591
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 8326
Swiss Prot O00144
Subcellular location Cell membrane
Synonyms FZD3; CD349; Frizzled-9; Fz-9; hFz9; FzE6; FZD9
Background Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Application Dilution
WB 1:500-2000
ELISA 1:500-1000