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    Jarid2/Jumonji Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated

    Overview
    Catalog # bs-11860R-A555
    Product Name Jarid2/Jumonji Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 555
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Jarid2/Jumonji
    Immunogen Range 315-365/1246
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 3720
    Swiss Prot Q92833
    Subcellular location Nucleus
    Synonyms JMJ; Protein Jumonji; Jumonji/ARID domain-containing protein 2; JARID2
    Background Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.