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    OTX1 + OTX2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated

    Catalog # bs-11958R-A488
    Product Name OTX1 + OTX2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
    Applications IF(IHC-P)
    Specificity This has 79% sequence similarty with CRX, which is specific to Retinal tissue.
    Reactivity Human, Mouse, Rat
    Conjugation ALEXA FLUOR® 488
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human OTX1 + OTX2
    Immunogen Range 30-80/354
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Gene ID 5015, 5013
    Subcellular location Nucleus
    Synonyms FLJ38361; Homeobox protein OTX 1; Homeobox protein OTX1; Homeobox protein OTX2; MCOPS 5; MCOPS5; MGC15736; MGC45000; Orthodenticle 1; Orthodenticle 2; Orthodenticle homeobox 1; Orthodenticle homeobox 2; Orthodenticle homolog 1; Orthodenticle homolog 2 Drosophila; Orthodenticle homolog 2; Orthodenticle1; Orthodenticle2; Otx 1; Otx 2; otx1; OTX1_HUMAN; otx2; OTX2_HUMAN.
    Background Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.