ICOS/CD278 Polyclonal Antibody

Applications

  • WB
  • IHC-P
  • IF(IHC-P)

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-2583R
Product Name ICOS/CD278 Polyclonal Antibody
Applications WB, IHC-P, IF(IHC-P)
Specificity This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77% non-contiguous sequence similarity in the corresponding immunogen region.
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ICOS
Immunogen Range 40-90/199
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID 29851
Swiss Prot Q9Y6W8
Subcellular location Extracellular
Synonyms AILIM; CD278; CVID1; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; ICOS
Background Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Application Dilution
WB 1:300-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200