CITED1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated

Applications

  • WB

Reactivity

  • Human
  • Mouse
Overview
Catalog # bs-2990R-A555
Product Name CITED1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
Applications WB
Reactivity Human, Mouse
Specifications
Conjugation ALEXA FLUOR® 555
Host Rabbit
Source KLH conjugated synthetic peptide derived from human CITED1
Immunogen Range 121-193/193
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 4435
Swiss Prot Q99966
Subcellular location Cytoplasm, Nucleus
Synonyms MSG1; Cbp/p300-interacting transactivator 1; Melanocyte-specific protein 1; CITED1
Background Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Application Dilution
WB 1:300-5000