LRP6 (Ser1490) Polyclonal Antibody

Applications

  • IHC-P
  • IF(IHC-P)
  • IF(ICC)

Reactivity

  • Human
  • Mouse
Overview
Catalog # bs-3253R
Product Name LRP6 (Ser1490) Polyclonal Antibody
Applications IHC-P, IF(IHC-P), IF(ICC)
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
Immunogen Range 1470-1520/1613
Modification Site Ser1490
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID 4040
Swiss Prot O75581
Subcellular location Cytoplasm
Synonyms ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6
Background Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Application Dilution
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200