MEK1/2(Ser218 + Ser222) Antibody

Applications

  • IHC-P
  • IF(IHC-P)

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-3270R
Product Name MEK1/2(Ser218 + Ser222) Antibody
Applications IHC-P, IF(IHC-P)
Specificity These phosphorylation sites are homologous to Ser222 + Ser226 in MEK2 and are the same across the listed species.
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human MEK1 around the phosphorylation site of Ser218/222
Immunogen Range 180-230/393
Modification Site Ser218 + Ser222
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID 56045605
Subcellular location Cytoplasm, Nucleus
Synonyms MAP2K1phospho S218/S222; Dual specicity mitogen activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAP/Erk kinase 1; Map2K1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEKK1; Mitogen activated protein kinase kinase 1; MKK 1; MKK1; PRKMK 1; PRKMK1;Protein kinase mitogen activated kinase 1 MAP kinase kinase 1; Protein kinase mitogen activated kinase 1; Protein kinase mitogen activated, kinase 1.
Background The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Application Dilution
IHC-P 1:200-400
IF(IHC-P) 1:50-200