| Overview |
| bs-5474R-A350 |
| MBP(Thr232) Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated |
| FCM, IF(IHC-P), IF(IHC-F), IF(ICC) |
| This antibody recognizes Thr229 in mice and Thr122 in rat |
| Human, Mouse, Rat |
| Dog, Cow, Pig, Horse, Chicken, Rabbit |
| Specifications |
| ALEXA FLUOR® 350 |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human MBP around the phosphorylation site of Thr232 |
| Thr232 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 4155 |
| P02686 |
| Cytoplasm, Cell membrane |
| Myelin basic protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein |
| The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
| Application Dilution |
| FCM |
1:20-100 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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