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    EMR1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

    Overview
    Catalog # bs-7058R-A647
    Product Name EMR1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
    Applications FCM, IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation ALEXA FLUOR® 647
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human EMR1
    Immunogen Range 732-747/886
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 2015
    Swiss Prot Q14246
    Subcellular location Extracellular
    Synonyms TM7LN3; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-like module receptor 1; EMR1 hormone receptor; EMR1; Adhesion G Protein-Coupled Receptor E1; ADGRE1; Cell surface glycoprotein F4/80
    Background The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1–3). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1–3). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.