Recombinant Human ACE2 Protein
|CROSS REACTIVE SPECIES DETAILS||Human|
An E.coli expression system produces recombinant Human ACE2 Protein, and the target gene encoding amino acids 243-369 is expressed with His Tag.
|PREDICTED MOLECULAR MASS||69.2kDa|
≥95% as determined by SDS-PAGE
Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5 % trehalose is added as a protectant before lyophilization.
|STORAGE||Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt. Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Angiotensin-converting enzyme 2 (ACE2) is an enzyme attached to the outer surface (cell membranes) of cells in the lungs, arteries, heart, kidney, and intestines. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1–7) (a vasodilator). ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7) making it a promising drug target for treating cardiovascular diseases. ACE2 also serves as the entry point into cells for some coronaviruses including Severe acute respiratory syndrome coronavirus 2.
For research use only. Not for use in clinical diagnostic procedures.