Complement C4 beta chain (52H10) Monoclonal Antibody

Applications

  • WB
  • IHC-P
  • IP

Reactivity

  • Human
Overview
Catalog # bsm-50255M
Product Name Complement C4 beta chain (52H10) Monoclonal Antibody
Applications WB, IHC-P, IP
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source Protein purified from Human plasma
Clonality Monoclonal
Clone # 52H10
Isotype IgG1 κ
Concentration 2ug/ul
Purification Purified by Protein G.
Storage HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Store for 1 year at -20°C from date of shipment.
Target
Gene ID 721
Swiss Prot P0C0L4
Synonyms CH; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4BD; C4B12; C4B_2; CPAMD3; Complement C4-A; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4A; CPAMD2
Background Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Application Dilution
WB 2.0 ug/ml
IHC-P 1:100-500
IP 5.0 ug