14-3-3 sigma (2E12) Monoclonal Antibody

Applications

  • IHC-P

Reactivity

  • Human
Overview
Catalog # bsm-52005R
Product Name 14-3-3 sigma (2E12) Monoclonal Antibody
Applications IHC-P
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant human 14-3-3 sigma protein, full length.
Clonality Monoclonal
Clone # 2.00E+12
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. Store at -20°C for 12 months.
Target
Gene ID 2810
Swiss Prot P31947
Synonyms 14-3-3 protein sigma; SFN; Epithelial cell marker protein 1; Stratifin; HME1
Background Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.1 Publication p53-regulated inhibitor of G2/M progression.
Application Dilution
IHC-P 1:200-400