WAPL Monoclonal Antibody

Applications

  • WB
  • IHC-P

Reactivity

  • Human
Overview
Catalog # bsm-54699R
Product Name WAPL Monoclonal Antibody
Applications WB, IHC-P
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Synthetic Peptide within N-terminal human WAPL
Clonality Monoclonal
Clone # 7C15
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 23063
Swiss Prot Q7Z5K2
Subcellular location Nucleus
Synonyms FOE antibody, Friend of EBNA2 (Epstein Barr virus nuclear protein 2) antibody, Friend of EBNA2 protein antibody, KIAA0261 antibody, OTTHUMP00000020004 antibody, WAPAL antibody, WAPL antibody, WAPL_HUMAN antibody, Wings apart like homolog antibody, Wings apart like homolog (Drosophila) antibody, Wings apart-like protein homolog antibody
Background Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400