CDC123 Monoclonal Antibody

Applications

  • WB
  • FCM

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-54706R
Product Name CDC123 Monoclonal Antibody
Applications WB, FCM
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Rabbit
Source Synthetic Peptide within C-terminal human CDC123.
Clonality Monoclonal
Clone # 1H42
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 8872
Swiss Prot O75794
Subcellular location Cytoplasm
Synonyms C10orf7 antibody, CD123_HUMAN antibody, CDC123 antibody, Cell division cycle 123 antibody, Cell division cycle 123 homolog antibody, Cell division cycle protein 123 homolog antibody, D123 antibody, HT 1080 antibody, HT-1080 antibody, Protein D123 antibody, PZ32 antibody
Background Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
Application Dilution
WB 1:300-5000
FCM 1:20-100