Midostaurin
| Overview | |
| Catalog # | bs-6781c-10mg |
| Product Name | Midostaurin |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 570.64 Formula: C35 H30 N4 O4 CAS Number: 120685-11-2 InChi Key: BMGQWWVMWDBQGC-AKZXJVOYSA-N InChi: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26+,32-,35+/m1/s1 Smiles: CN([C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)N1C3=C(C4=CC=CC=C14)C1CNC(=O)C=1C1=C3N2C2C=CC=CC=21)C(=O)C1C=CC=CC=1 Purity: 98.0 Solubility: Soluble in DMSO, not soluble in water. Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | Midostaurin, also known as PKC-412, PKC-412A and CGP 41251; is a synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was approved in 2017. |