ODQ

Overview
Catalog #	bs-83167c-25mg
Product Name	ODQ
Specifications
Storage Buffer	Pale-yellow solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2 ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1 ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
Description	CAS Number: 41443-28-1 Chemical Name: Soluble guanylyl cyclase inhibitor Molecular Weight: 187.15 Formula: C9H5N3O2 Solubility: DMSO (40 mg/ml) Physical Properties: Pale-yellow solid Purity: 98% by HPLC NMR (conforms)