beta Catenin (Ser37) Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated

Applications

WB
IF(ICC)

Reactivity

Human
Mouse
Rat

Predicted Reactivity

Pig
Chicken
Rabbit

Overview
Catalog #	bs-12854R-A555
Product Name	beta Catenin (Ser37) Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
Applications	WB, IF(ICC)
Reactivity	Human, Mouse, Rat
Predicted Reactivity	Pig, Chicken, Rabbit
Specifications
Conjugation	ALEXA FLUOR® 555
Host	Rabbit
Source	KLH conjugated synthetic phosphopeptide derived from human beta Catenin around the phosphorylation site of Ser37
Modification Site	Ser37
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	1499
Subcellular location	Cytoplasm, Nucleus, Cell membrane, Extracellular matrix
Synonyms	beta Catenin phospho S37; beta Catenin phospho Ser37; p-beta Catenin S37; p-beta Catenin Ser37; p-beta Catenin phospho S37; beta-catenin; beta catenin; CTNNB1; CHBCAT; CTNNB1; CTNNB; PRO2286; Cadherin associated protein; Catenin cadherin associated protein, beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; b-catenin; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289..
Background	The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Application Dilution
WB	1:300-5000
IF(ICC)	1:50-200

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