HMGN2/HMG17 Polyclonal Antibody, Biotin Conjugated

Applications

IHC-P

Reactivity

Mouse
Rat

Overview
Catalog #	bs-18054R-Biotin
Product Name	HMGN2/HMG17 Polyclonal Antibody, Biotin Conjugated
Applications	IHC-P
Reactivity	Mouse, Rat
Specifications
Conjugation	Biotin
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human HMGN2/HMG17:2-60/90
Immunogen Range	2-60/90
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C for 12 months.
Target
Gene ID	3151
Swiss Prot	P05204
Subcellular location	Cytoplasm, Nucleus
Synonyms	High mobility group (nonhistone chromosomal) protein 17; high mobility group nucleosomal binding domain 2; High mobility group nucleosome-binding domain-containing protein 2; High mobility group protein N2; HMG17; HMGN2; HMGN2_HUMAN; MGC5629; Non histone chromosomal protein HMG 17; Non-histone chromosomal protein HMG-17; Nonhistone chromosomal protein HMG 17; nonhistone chromosomal protein hmg-17.
Background	The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (15). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (13,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (13). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (13). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2). Post-translational modifications : Phosphorylation favors cytoplasmic localization. Similarity : Belongs to the HMGN family.
Application Dilution
IHC-P	1:200-400

Search our catalog of hundreds of thousands of products