| Overview |
| bs-3121R-A750 |
| Crk isoform 2 (Tyr221) Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| Others |
| Human, Mouse, Rat, Dog, Horse, Chicken, Rabbit |
| Specifications |
| ALEXA FLUOR® 750 |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human Crk p38 around the phosphorylation site of Tyr221 [GP(p-Y)AQ] |
| Tyr221 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 1398 |
| Cytoplasm, Cell membrane |
| Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK |
| The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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