| Overview |
| bs-3837R-A647 |
| Hamartin/TSC1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated |
| WB |
| Sheep |
| Human, Mouse, Rat, Dog, Cow, Pig, Horse |
| Specifications |
| ALEXA FLUOR® 647 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Hamartin |
| 131-230/1164 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 7248 |
| Q92574 |
| Cytoplasm, Cell membrane |
| LAM; TSC1; Tuberous sclerosis 1 protein; TSC1_HUMAN. |
| Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology. |
| Application Dilution |
| WB |
1:300-5000 |
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