| Overview |
| bs-6465R-A750 |
| Girdin (Ser1417) Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated |
| WB, FCM |
| Human |
| Mouse, Rat, Dog, Cow, Pig, Horse |
| Specifications |
| ALEXA FLUOR® 750 |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human Girdin around the phosphorylation site of Ser1417 |
| Ser1417 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 55704 |
| Q3V6T2 |
| Cytoplasm, Cell membrane |
| APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212; Akt phosphorylation enhancer; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Girders of actin filament; Hook-related protein 1; CCDC88A |
| Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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