| Overview |
| bs-9041R-A647 |
| PDZD6 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated |
| WB |
| Human, Mouse, Rat |
| Specifications |
| ALEXA FLUOR® 647 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human PDZD6 |
| 301-400/942 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 27152 |
| Q9ULD6 |
| Cytoplasm, Cell membrane, Cytoskeleton |
| Protein inturned; Inturned planar cell polarity effector homolog; PDZ domain-containing protein 6; INTU; KIAA1284; PDZD6; PDZK6; INTU_HUMAN. |
| Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). |
| Application Dilution |
| WB |
1:300-5000 |
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