LCN2, ALEXA FLUOR® 594 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bsm-41179M-A594 |
| Product Name | LCN2, ALEXA FLUOR® 594 Conjugated |
| Applications | WB |
| Reactivity | Human |
| Specifications | |
| Conjugation | ALEXA FLUOR® 594 |
| Host | Mouse |
| Source | Recombinant human LCN2 |
| Immunogen Range | 21-198/198 |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/ml |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 3934 |
| Swiss Prot | P80188 |
| Subcellular location | Secreted |
| Synonyms | Lipocalin 2; Neutrophil Gelatinase associated Lipocalin; 25 kDa alpha 2 microglobulin related subunit of MMP9; Alpha 2 microglobulin related protein; HGNC:6526; HNL; Lcn 2; LCN-2; Neutrophil gelatinase associated lipocalin precursor; NGAL; Oncogene 24p3; P25; SV40 induced 24P3 protein. 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Migration stimulating factor inhibitor; MSFI; Neutrophil gelatinase associated lipocalin precursor; Neutrophil gelatinase-associated lipocalin; NGAL_HUMAN; Oncogenic lipocalin 24p3; Siderocalin; siderocalin LCN2; SV40 induced 24P3 protein. |
| Background | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |
| Application Dilution | |
| WB | 1:300-5000 |
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