| Overview |
| bsm-52747R |
| SIRT5 (4C1) Monoclonal Antibody |
| WB, IHC-P |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Human SIRT5 between 150-250 amino acids |
| Monoclonal |
| 4C1 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at -20°C for 12 months. |
| Target |
| 23408 |
| Q9NXA8 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5, SIR2-like protein 5, SIRT5 |
| NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
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