| Overview |
| bsm-54439R |
| NXF1 (1G8) Monoclonal Antibody |
| WB, IF(ICC), IP |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| Recombinant protein within c-terminal human NXF1. |
| Monoclonal |
| 1G8 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at -20°C for 12 months. |
| Target |
| 10482 |
| Q9UBU9 |
| Cytoplasm, Nucleus |
| Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP; NXF1; MEX67; TAP |
| Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(ICC) |
1:50-200 |
| IP |
1-2ug |
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