| Overview |
| bs-42465P-Biotin-100ug |
| Recombinant human MLKL protein, GST & His, Biotin Conjugated |
| Others |
| Others |
| Specifications |
| Biotin |
| Recombinant human MLKL protein in E.coli with GST & His. It contains the amino acid sequence ofGST & His |
| Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization. |
| Target |
| Q8NB16 |
| This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. |
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