| Overview |
| bs-43155P-Biotin-100ug |
| Recombinant SARS-Cov-2 Spike RBD protein (BF.7/Omicron), His (HEK293), Biotin Conjugated |
| Others |
| Others |
| Specifications |
| Biotin |
| Recombinant SARS-Cov-2 Spike RBD protein (BF.7/Omicron) is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 319-537/1273 |
| Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization. |
| Target |
| P0DTC2 |
| The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein. |
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