| OVERVIEW |
|
| CATALOG # |
bs46108P |
| PRODUCT NAME |
Recombinant SARS-CoV-2 Spike protein fragment 2
|
| CROSS REACTIVE SPECIES DETAILS |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| CONJUGATION |
Unconjugated |
| SOURCE |
An E.coli expression system produces recombinant SARS-CoV-2 S protein fragment 2, and the target gene encoding Tyr1047-Gln1201 is expressed with N-His Tag |
| EXPRESSION SYSTEM |
E.coli |
| TAG |
N-His Tag |
| PREDICTED MOLECULAR MASS |
19.69kDa |
| PURITY |
>95% as determined by SDS-PAGE |
| FORMULATION |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). 5 % trehalose is added as a protectant before lyophilization. |
| STORAGE |
Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt. Avoid repeated freeze/thaw cycles. |
| ENDOTOXIN LEVEL |
N/A |
| ACTIVITY ASSAY |
N/A |
| TARGET |
|
| ACCESSION # |
QHD43416.1 |
| SYNONYMS |
Spike glycoprotein, Spike protein |
| BACKGROUND |
Protein S (PROS1) is a glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor-binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
| NOTE |
For research use only. Not for use in clinical diagnostic procedures. |
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