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Caspase 3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated

Applications

  • WB
  • IF(IHC-P)
  • IF(ICC)

Reactivity

  • Human
  • Mouse
  • Rat
  • Bovine
  • Pig
  • Chicken
  • Sheep
  • Rabbit
  • Others
  • Monkey
Overview
Catalog # bs-0081R-A488
Product Name Caspase 3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
Applications WB, IF(IHC-P), IF(ICC)
Reactivity Human, Mouse, Rat, Bovine, Pig, Chicken, Sheep, Rabbit, Others, Monkey
Specifications
Conjugation ALEXA FLUOR® 488
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Caspase 3(Active)
Immunogen Range 1-100/277
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 836
Swiss Prot P42574
Subcellular location Cytoplasm
Synonyms CPP32; SCA-1; CPP32B; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; CASP3
Background Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Application Dilution
WB 1:300-5000
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200