Overview |
bs-0113R-Cy3 |
SOCS1 Polyclonal Antibody, Cy3 Conjugated |
IF(IHC-P), IF(IHC-F), IF(ICC) |
Human |
Mouse, Rat, Cow, Pig, Horse, Rabbit |
Specifications |
Cy3 |
Rabbit |
KLH conjugated synthetic peptide derived from human Socs 1 |
121-211/211 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
8651 |
O15524 |
Cytoplasm, Nucleus |
JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; Suppressor of cytokine signaling 1; JAK-binding protein; STAT-induced STAT inhibitor 1; Tec-interacting protein 3; TIP-3; SOCS1 |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. |
Application Dilution |
IF(IHC-P) |
1:50-200 |
IF(IHC-F) |
1:50-200 |
IF(ICC) |
1:50-200 |