HCV-NS4a Polyclonal Antibody, Biotin Conjugated


  • IHC-F


  • Virus
Catalog # bs-0213R-Biotin
Product Name HCV-NS4a Polyclonal Antibody, Biotin Conjugated
Applications IHC-F
Reactivity Virus
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from HCV-NS4a
Immunogen Range 1658-1711/3010
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Subcellular location Cytoplasm, Cell membrane
Synonyms HCV-NS4a; Non-structural protein 4A; NS4A;POLG_HCVBK.
Background Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus classified within the genus Hepacivirus in the family Flaviviridae. The nonsegmented HCV genome is 9.6-kb and encodes a long polyprotein that is cleaved by cellular and viral proteases into at least 10 distinct products. The N-terminal region of this polyprotein encodes the viral structural proteins: core and two envelope glycoproteins, E1 and E2. The remainder of the polyprotein encodes nonstructural (NS) proteins: p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B. NS4A is the smallest NS protein. It encodes an N-terminal hydrophobic alpha-helix that anchors NS3-4A to cellular membranes, a middle cofactor peptide that forms a beta-strand and contributes to proper folding of the NS3 serine protease domain, and a C-terminal acidic region that forms an alpha-helix at low pH.
Application Dilution
IHC-F 1:100-500