C5a anaphylatoxin Polyclonal Antibody, Cy5.5 Conjugated

Applications

  • IF(IHC-P)

Reactivity

  • Mouse
Overview
Catalog # bs-0324R-Cy5.5
Product Name C5a anaphylatoxin Polyclonal Antibody, Cy5.5 Conjugated
Applications IF(IHC-P)
Reactivity Mouse
Specifications
Conjugation Cy5.5
Host Rabbit
Source KLH conjugated synthetic peptide derived from mouse C5a (725-770aa)
Immunogen Range 700-755/1680
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target
Gene ID 15139
Swiss Prot P06684
Subcellular location Secreted
Synonyms C5; He; C5a; Complement C5; Hemolytic complement; Hc
Background Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Application Dilution
IF(IHC-P) 1:50-200