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ATBF1 Polyclonal Antibody, Biotin Conjugated


  • IHC-P
  • IHC-F


  • Rat

Predicted Reactivity

  • Human
  • Mouse
  • Dog
  • Cow
  • Sheep
  • Horse
  • Chicken
  • Rabbit
Catalog # bs-11805R-Biotin
Product Name ATBF1 Polyclonal Antibody, Biotin Conjugated
Applications ELISA, IHC-P, IHC-F
Reactivity Rat
Predicted Reactivity Human, Mouse, Dog, Cow, Sheep, Horse, Chicken, Rabbit
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ATBF1
Immunogen Range 301-400/3703
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Subcellular location Nucleus
Synonyms Alpha fetoprotein enhancer binding protein; AT binding transcription factor 1; AT mot binding factor; ATBT; ZFHX3; ZFHX3_HUMAN.
Background AT-motif binding factor 1 (ATBF1) binds to the AT-rich core sequence element in the human a-fetoprotein enhancer (1). Alternative splicing generates the ATBF1-A and ATBF1-B (2,3). While ATBF1-A contains a 920-amino acid extension at the N-terminus, both ATBF1-A and ATBF1-B contain 4 DNA-binding homeobox domains (2,3). Additionally, ATBF1-A contains 23 zinc finger motifs while ATBF1-B contains 18 zinc finger motifs (13). The N-terminal extension unique to ATBF1-A has transcriptional repressor activity (4). In the small intestine, ATBF1-A inhibits expression of the brushborder enzyme aminopeptidase-N through direct binding to the AT motif element (5). Besides functioning in transcription regulation, ATBF1 also functions in ATPase activity (6). ATPase activity associated with ATBF1-A is DNA/RNA-dependent and requires both homeobox domains and zinc finger motifs (6). ATBF1 is highly expressed in spleen and brain tissues (7). The gene encoding human ATBF1 maps to chromosome 16q22.3-q23.1 (8).
Application Dilution
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500