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    Adracalin Polyclonal Antibody, Cy5 Conjugated

    Catalog # bs-11807R-Cy5
    Product Name Adracalin Polyclonal Antibody, Cy5 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Conjugation Cy5
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Adracalin
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Synonyms AAA; AAAS; AAASb; Achalasia adrenocortical insufficiency alacrimia Allgrove triple A; Achalasia adrenocortical insufficiency alacrimia; ADRACALA; Aladin; Allgrove triple A; DKFZp586G1624; GL003; AAAS_HUMAN.
    Background Aladin (Adracalin) belongs to a family of WD repeat-containing proteins. These proteins have a wide variety of functions, including signal transduction regulation, RNA processing and transcription. Aladin plays a role in peripheral and central nervous system development. It is widely expressed, with the highest expression seen in pituitary gland, corpus callosum, cerebellum, adrenal gland and gastrointestinal structures. Defects in Aladin cause the autosomal recessive disorder achalasia-addisonianism-alacrima (triple A) syndrome. Triple A syndrome is characterized by achalasia, alacrima and adrenocortico-tropin-resistant adrenal insufficiency. Robust expression in neural systems associated with cognitive, motor and sensory functions is consistent with the myriad of symptoms experienced by patients with triple A syndrome.