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SPOCK1/Testican 1 Polyclonal Antibody, Biotin Conjugated


  • WB


  • Human

Predicted Reactivity

  • Mouse
  • Rat
  • Dog
  • Sheep
  • Pig
  • Rabbit
Catalog # bs-11965R-Biotin
Product Name SPOCK1/Testican 1 Polyclonal Antibody, Biotin Conjugated
Applications WB, ELISA
Reactivity Human
Predicted Reactivity Mouse, Rat, Dog, Sheep, Pig, Rabbit
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human SPOCK1/Testican 1
Immunogen Range 51-150/439
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Subcellular location Secreted, Extracellular matrix
Synonyms Sparc/osteonectin, cwcv and kazal like domains proteoglycan 1; SPOCK; Testican 1; Testican1; Testican-1;; TIC1; TICN1; TICN1_HUMAN.
Background The Testican family, also designated the BM-40/SPARC/osteonectin family, is composed of highly conserved, extracellular, calcium-binding, sulfate proteoglycans. Expression of Testicans is detected in a variety of tissues, but is most abundant in brain. Family members include Testican-1, Testican-2, Testican-3 and an amino-terminal splice variant of Testican-3, designated N-Tes. Most Testicans inhibit MT-MMPs, thereby inhibiting the activity of pro-MMP-2. Testican-1 is specifically expressed in the thalamus of the brain, and is upregulated in activated astroglial cells of the cerebrum where it mediates neuronal attachment and matrix metalloproteinase activation. After a neural injury, such as a cerebral stroke, Testican-1 expression is upregulated in astrocyte cells in order to inhibit the ability of the protein Neuro-2a to form neurite extensions. Testican-1 is also a component of joint and of the growth plate cartilage that may participate in the regulation of matrix turnover.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000