| Overview |
| bs-13224R-A350 |
| FUBP1/2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| This antibody detects both FUBP1 and FUBP2 (KHSRP) |
| Mouse |
| Human, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit, Zebrafish |
| Specifications |
| ALEXA FLUOR® 350 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human FUBP1 |
| 551-644/644 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 8880 |
| Q96AE4 |
| Nucleus |
| Far upstream element-binding protein 1; FUBP1; FBP; FUSE-binding protein 1; DNA helicase V; hDH V; Far upstream element-binding protein 2; KHSRP; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75; FBP2; FUBP2 |
| FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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