Centaurin beta 2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

Applications

WB
IF(IHC-P)
IF(IHC-F)
IF(ICC)

Predicted Reactivity

Human
Mouse
Rat
Dog
Cow
Sheep
Pig
Horse
Rabbit

Overview
Catalog #	bs-13842R-A647
Product Name	Centaurin beta 2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
Applications	WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Predicted Reactivity	Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit
Specifications
Conjugation	ALEXA FLUOR® 647
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human Centaurin beta 2
Immunogen Range	101-200/778
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	23527
Swiss Prot	Q15057
Subcellular location	Cytoplasm
Synonyms	ACAP 2; ACAP2; ACAP2_HUMAN; ANK repeat and PH domain-containing protein 2; Ankyrin repeat; Arf GAP with coiled coil ANK repeat and PH domains 2; ARF GAP with coiled coil; Arf-GAP with coiled-coil; CENT B 2; Centaurin beta2; Centaurin-beta-2; CENTB 2; CENTB2; Cnt b2; Cnt-b2; Cntb2; KIAA0041; Pleckstrin homology domains 2; Similar to yeast ZINC FINGER PROTEIN GCS1.
Background	The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins mainly regulate membrane traffic. ACAP2 is a member of the centaurin GTPase-activating protein (GAP) family, which comprises a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. ACAP1 and ACAP2 are both widely expressed in peripheral, tubular membranes and usually interact with each other in various tissues. GAP activity of both ACAP1 and ACAP2 is dependent upon phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]. ACAP2 associates with ARF1 and ARF6. Overexpression of ACAP2 blocks the formation of ARF6-dependent protrusions. K1L is a protein required for growth of the Vaccinia Virus that interacts with the ankyrin repeats of ACAP2.
Application Dilution
WB	1:300-5000
IF(IHC-P)	1:50-200
IF(IHC-F)	1:50-200
IF(ICC)	1:50-200

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